Premium
[P83B]: Bioelectric properties of developing neuroectodermal stem cells
Author(s) -
Jelitai M.,
Anděrová M.,
Varga B.,
Chvátal A.,
Madarász E.
Publication year - 2006
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2006.09.146
Subject(s) - czech , citation , glioblastoma , library science , medicine , computer science , philosophy , cancer research , linguistics
In about 50% of non-differentiated pass-cells, blocking GJs resulted in the appearance of outwardly rectifying VD currents. These VD currents were only partially inhibited by tetraethylammonium (TEA, 5mM) but were completely blocked by 2 mM 4-AP. In addition to passive conductance, KDR currents were also reduced by GRA in non-differentiated pass+VD cells. Residual VD currents were not or only partially reduced by TEA, but were completely blocked by 4-AP. The pharmacological properties of KDR changed during development. In non-differentiated pass+VD cells KDR currents were only partially reduced by TEA, while 4-AP almost completely diminished the current. In NE-4C neurons, on the other hand TEA exerted a more profound (~60 %) blocking effect. Inhibiting KDR by TEA and 4-AP