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[P79]: Analysis of genes regulating migration and proliferation of neuronal progenitor cells in the cerebellum
Author(s) -
Roelandse M.,
Levelt C.N.
Publication year - 2006
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2006.09.141
Subject(s) - cerebellum , progenitor cell , neuroscience , citation , computer science , library science , psychology , biology , stem cell , genetics
group at P4 compared to P14. Comparison of IE and IC groups revealed no change in these parameters due to ethanol treatment. Gavage alone increased production of ROS and decreased mitochondrial membrane potential compared to handled-only control at P14 but not P4. As a result, both IC and IE were different than HC 12–24 h after treatment on P14. This emphasized the significance of HC and IC controls in the design and interpretation of animal models of ethanol neurotoxicity in the developing brain. The present study demonstrated there was no difference in production of ROS or mitochondrial membrane potential in cerebellar granule cells following exposure to ethanol in vivo. These findings contribute to understanding the role of oxidative stress in ethanol toxicity in cerebellar granule cells.