Premium
[P72]: Gamma interferon (γ‐IFN) modulates the astrocytic support of the neuronal survival
Author(s) -
AbdElBasset E.
Publication year - 2006
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2006.09.134
Subject(s) - citation , library science , neuroscience , medicine , psychology , computer science
synaptic enrichment of AMPARs, in the absence of 2B, is a cell autonomous phenomenon. Focal application of glutamate (100 M), in conjunction with voltage clamp recordings, showed suppression of NMDAR responses in 2B null cultures up to 16 DIV (90% suppression at 14–16DIV). However, pharmacological analysis of wildtype neurons at this age showed a significant contribution of the NMDAR response was due to 2A subunits (58–86%). This demonstrates the requirement for 2B signaling in subsequent expression of functional NR2A containing surface receptors. These studies reveal two important yet distinct roles for the NR2B protein in regulating cortical synapse maturation; first, NR2B expression regulates insertion of AMPARs at synapses, and second, expression of NR2B protein is required for the subsequent functional insertion of NR2A containing receptors at the neuronal membrane.