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[P61]: Presynaptic TrkB signaling mediates axon arbor growth and synapse maturation during the establishment of retinotectal synaptic connectivity
Author(s) -
CohenCory S.,
Marshak S.,
Matthews B.J.,
Sanchez A.L.,
Nikolakopoulou A.K.,
Meynard M.
Publication year - 2006
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2006.09.124
Subject(s) - neuroscience , synapse , cognitive science , biology , psychology
tral portion of the growth cone. Phosphorylation of synapsin I by cAMP-dependent protein kinase (PKA) causes the dissociation of the protein from the SV membrane, allowing diffusion of the vesicles to the periphery of the growth cone and enhancing their rate of recycling. A similar mechanism also takes place at mature synapses, where cAMP-induced phosphorylation of synapsin I largely accounts for the modulatory effects of PKA in the potentiation of SV exocytosis. These results indicate that molecular mechanisms similar to those operating at mature nerve terminals are active in developing neurons to regulate the SV life cycle prior to synaptogenesis. Moreover, the cAMP/synapsin pathway may underlie the synaptogenetic effect of synapsin by triggering the structural rearrangements which lead to the formation of a mature secretory compartment.