[P30]: The roles of BMP and bHLH transcription factors in sympathetic nervous system development | Zendy

Morikawa Y. | Zendy; Cserjesi P. | Zendy

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[P30]: The roles of BMP and bHLH transcription factors in sympathetic nervous system development

Author(s) -

Morikawa Y.,

Cserjesi P.

Publication year - 2006

Publication title -

international journal of developmental neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.761

H-Index - 88

eISSN - 1873-474X

pISSN - 0736-5748

DOI - 10.1016/j.ijdevneu.2006.09.094

Subject(s) - citation , library science , transcription (linguistics) , world wide web , computer science , neuroscience , biology , linguistics , philosophy

an independent study by an additional group. We have therefore begun to characterize the function of AGC1 in cell and animal models. We have developed mice with a targeted disruption of AGC1. Remarkably, the AGC1-deficient animals have profound decrease in the levels of structural myelin proteins. This appears to be due to a significant decrease in the levels of N-acetylaspartate (NAA), which is important in myelin lipid synthesis. Further characterization of this model will shed light on the role of AGC1 in brain function and may shed light on a molecular and cellular pathology that may contribute to autism susceptibility.

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