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[P25]: CCR7, CCR8, CCR9 and CCR10 in the mouse hippocampus during and after pilocarpine induced status epilepticus
Author(s) -
Tang F.R.,
Liu J.X.,
Cao X.,
Tang Y.C.,
Liu Y.
Publication year - 2006
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2006.09.089
Subject(s) - epilepsy , pilocarpine , neuroscience , status epilepticus , clinical neuroscience , brain research , psychology , psychiatry , neurology
Objectives: Neurotrophic factors play key roles in the developing auditory pathway including the sensory epithelium of the inner ear, and structures involved in the central nervous processing of auditory stimuli. In the present investigation, we explored a possible implication of variant BDNF in the susceptibility to chronic tinnitus. Methods: 222 subjects complaining of chronic tinnitus were recruited from a tinnitus clinic and underwent detailed neurootological examinations including otoscopy, stapedius reflexes, middle ear pressure measurements, pure tone audiometry, tinnitus pitch and loudness matches. Subjects were genotyped for a biallelic BDNF missense variant (Val66Met). Prevalence of the substitution was compared to the prevalence in an ethnically homogenous group of healthy controls (N = 317). Results: Carriers of the Met variant were significantly less likely to develop chronic tinnitus with comorbid hearing impairment (p = .02, OR = 1.62, 95% CI = 1.1–2.5). When no assumptions of dominance were made for the minor allele, the Met allele still conferred protection against tinnitus with hearing impairment (p = .05, OR = 1.42, 95% CI = 1.0–2.0). Conclusions: The present study suggests a role of variant BDNF in modulating the genetic susceptibility to chronic tinnitus with hearing impairment. Possible implications of this finding include a differential response to the pharmacological treatment of tinnitus, and specifically, to the neurotrophic effects of antidepressants.