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[S47]: Synaptic plasticity in learning and memory
Author(s) -
Wang Y.T.
Publication year - 2006
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2006.09.057
Subject(s) - citation , synaptic plasticity , library science , cognitive science , psychology , computer science , neuroscience , medicine , receptor
Blockade of MAP kinase activity inhibited the SHP-2mediated increase in neurogenesis, indicating that this is the likely pathway used by NS SHP-2. Together, these results indicate that SHP-2 plays a key role in integrating extrinsic signals, and functions to promote neurogenesis at the same time that it inhibits gliogenesis. We are currently investigating whether the neuronal versus glial ratio is altered in a mouse model of Noonan syndrome, with the ultimate goal of determining whether this accounts for the cognitive impairments in NS patients.