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[S43]: Development of the dentate neurogenic niche
Author(s) -
Pleasure S.
Publication year - 2006
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2006.09.052
Subject(s) - pleasure , citation , psychology , pain and pleasure , library science , neuroscience , computer science
The dentate gyrus is one of the two locations in the adult rodent brain with ongoing neurogenesis. The ability to produce new neurons in the dentate is dependent on the relocation of neurogenic stem cells from the dentate ventricular zone to the hilus and later the subgranular zone during late prenatal and early postnatal development. There is abundant emphasis on the components of the adult neurogenic niche in the dentate but little is known of the processes controlling development of this niche. In this talk I will describe a conceptual framework for understanding the development of the dentate neurogenic niche, some of the key developmental regulatory events and discuss data showing that the chemokine SDF1 is a key regulator shaping the development of the dentate neurogenic niche.