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[S40]: Dissociation of corticothalamic and thalamocortical axon targeting by an ephA7‐mediated mechanism
Author(s) -
Levitt P.,
Torii M.
Publication year - 2006
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2006.09.048
Subject(s) - citation , neuroscience , dissociation (chemistry) , library science , computer science , psychology , chemistry
the progenitor population. In human, NF1 mutation predisposes to benign, incurable peripheral nerve tumors (neurofibromas). We prospectively identified EGFR+; p75+ cells by FACS analysis of human neurofibromas. These data demonstrate that an EGFR+ neural progenitor exists in developing peripheral nerve, and is amplified in Nf1 mutants. We hypothesize that expansion of a progenitor population in Nf1 mutant peripheral nerves contributes to tumorigenesis in NF1.
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