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[S16]: Neural stem and progenitor cells in cortical development
Author(s) -
Kriegstein A.R.
Publication year - 2006
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2006.09.021
Subject(s) - neural stem cell , citation , library science , progenitor cell , progenitor , neuroscience , cognitive science , stem cell , psychology , computer science , biology , genetics
cell population (the stem zone) from differentiation by inhibiting Retinoid synthesis in presomitic mesoderm, while later somitederived Retinoic acid (RA) attenuates FGF signalling and promotes neural and neuronal differentiation. The timing of RA production in the body axis is thus, key to preserving the stem zone. I will describe experiments which show that onset of Retinoid synthesis is controlled by canonical Wnt signalling. FGF promotes Wnt8c in the neuroepithelium, which persists after FGF declines and relays only some FGF actions; both FGF andWnt signalling inhibit neuronal differentiation, but only FGF interferes with RA transduction. Furthermore, as FGF declines, Wnt signals now promote RA synthesis. Our findings define a directional signalling relay, which ensures the spatial separation of the temporal events of neurogenesis and identify a novel role for Wnt signals in controlling the timing of the FGF/Retinoid differentiation switch. We have also developed a new assay that allows us to monitor neurogenesis in real time and this is being used to address how extrinsic factors, such as FGF, regulate cell behaviour in the extending neural axis.