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[S10]: High‐resolution analysis of genome copy number variation in autism
Author(s) -
Sebat J.,
Lakshmi B.,
Troge J.,
Martin C.,
Spence S.,
Ledbetter D.,
Gilliam T.C.,
Ye K.,
Geschwind D.,
Sutcliffe J.,
Wigler M.
Publication year - 2006
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2006.09.013
Subject(s) - columbia university , library science , university hospital , center (category theory) , research center , gerontology , medicine , sociology , family medicine , media studies , computer science , chemistry , pathology , crystallography
scaffold, and are important for generating, maintaining, and regulating spine shape. To examine more directly the link between cadherin actions and synapse function at more mature sites, we have examined the relationship between N-cadherin and AMPA receptor localization following synaptic stimulation using a glycine-based, chemical-LTP protocol. N-cadherin and AMPA receptors typically colocalize. Following stimulation, AMPA receptors are increased at synapses, but in neurons exposed to agents that interfere with N-cadherin based adhesion, AMPA receptor recruitment is abrogated. Thus, synaptic N-cadherin appears critical for the local recruitment or retention of AMPA receptors. Changes in N-cadherin levels have been correlated with synaptic potentiation and this might be expected to provoke changes in synapse shape. These data suggest that cadherins may serve to coordinate synapse structure and function. Supported by NIH R01 NS37731 (NINDS).