Open AccessAssociation between serum uric acid and ischemic stroke in patients with nonvalvular paroxysmal atrial fibrillation
Author(s) -
Nermin Bayar,
Selçuk Küçükseymen,
Ramazan Güven,
Zehra Erkal,
Erkan Köklü,
İsa Öner Yüksel,
Göksel Çağırcı,
Şakir Arslan
Publication year - 2017
Publication title -
international journal of the cardiovascular academy
Language(s) - English
Resource type - Journals
eISSN - 2618-6012
pISSN - 2405-8181
DOI - 10.1016/j.ijcac.2016.09.003
Subject(s) - medicine , atrial fibrillation , cardiology , paroxysmal atrial fibrillation , ischemic stroke , stroke (engine) , uric acid , ischemia , mechanical engineering , engineering
Objective: In this study, we aimed to investigate the value of serum uric acid levels in predicting stroke and transient ischemic attacks among patients with paroxysmal AF.Methods: We enrolled patients with paroxysmal AF. Clinical and demographic features of the patients were recorded, and CHA2DS2VASC scores were calculated. Uric acid levels were also recorded from biochemistry results. Patient groups with and without history of stroke and transient ischemic attack were compared for their serum uric acid levels.Results: A total of 180 patients were enrolled in this study, of whom 62 had a history of ischemic stroke/transient ischemic attack (symptomatic group). CHA2DS2VASC score in the symptomatic group was 4.7 ± 1.2 while it was 2.6 ± 1.4 in the asymptomatic group (<0.001). It was also shown that uric acid levels were higher in the symptomatic group when compared to the asymptomatic group (7.64 ± 1.12 mg/dl vs 5.06 ± 1.16 mg/dl, p < 0.001, respectively). Multivariate analysis revealed that a serum uric acid level higher than 6.35 mg/dl was independently associated with having a history of stroke/transient ischemic attack.Conclusion: Assessment of uric acid levels in addition to CHA2DS2VASC score might be useful in patients with paroxysmal AF to select patients with higher risk of stroke/transient ischemic attack