SARS-CoV-2 detection and sequencing in heart tissue associated with myocarditis and persistent arrhythmia: A case report | Zendy

Diego Egas | Zendy; Juan José Guadalupe | Zendy; Belén Prado-Vivar | Zendy; Mónica Becerra-Wong | Zendy; Sully Márquez | Zendy; Stalin Bismarck Castillo | Zendy; Johanna Latta | Zendy; Francisco Javier Yate Rodríguez | Zendy; Giovanni Escorza | Zendy; Gabriel Trueba | Zendy; Michelle Grunauer | Zendy; Verónica Barragán | Zendy; Patricio RojasSilva | Zendy; Paúl Cárdenas | Zendy

Open Access

SARS-CoV-2 detection and sequencing in heart tissue associated with myocarditis and persistent arrhythmia: A case report

Author(s) -

Diego Egas,

Juan José Guadalupe,

Belén Prado-Vivar,

Mónica Becerra-Wong,

Sully Márquez,

Stalin Bismarck Castillo,

Johanna Latta,

Francisco Javier Yate Rodríguez,

Giovanni Escorza,

Gabriel Trueba,

Michelle Grunauer,

Verónica Barragán,

Patricio RojasSilva,

Paúl Cárdenas

Publication year - 2021

Publication title -

idcases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.319

H-Index - 13

ISSN - 2214-2509

DOI - 10.1016/j.idcr.2021.e01187

Subject(s) - medicine , myocarditis , covid-19 , cardiology , cardiac arrhythmia , virology , atrial fibrillation , infectious disease (medical specialty) , outbreak , disease

BackgroundSARS-CoV-2 uses the human cell receptor angiotensin-converting enzyme (ACE2). ACE2 is widely present in the cardiovascular system including the myocardium and the conduction system. COVID-19 patients that present severe symptoms have been reported to have complications involving myocardial injuries caused by the virus. Here we report the detection of SARS-CoV-2 by whole genome sequencing in the endocardium of a patient with severe bradycardia.Case presentationWe report a case of a 34-year-old male patient with COVID-19 tested by PCR, he started with gastrointestinal symptoms, however, he quickly deteriorated his hemodynamic state by means of myocarditis and bradycardia. After performing an endocardium biopsy, it was possible to identify the presence of SARS-CoV-2 in the heart tissue and to sequence its whole genome using the ARTIC-Network protocol and a modified tissue RNA extraction method. The patient’s outcome was improved after a permanent pacemaker was implanted.ConclusionsIt was possible to identify a SARS-CoV-2 clade 20A in the endocardium of the reported patient.

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