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A cautionary tale of false-negative nasopharyngeal COVID-19 testing
Author(s) -
Sean S.M. Bullis,
Jessica W. Crothers,
S. Wayne,
Andrew J. Hale
Publication year - 2020
Publication title -
idcases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.319
H-Index - 13
ISSN - 2214-2509
DOI - 10.1016/j.idcr.2020.e00791
Subject(s) - medicine , covid-19 , sputum , false negative reactions , pre and post test probability , polymerase chain reaction , diagnostic test , pathology , disease , infectious disease (medical specialty) , pediatrics , genetics , tuberculosis , biology , gene , outbreak
There remains diagnostic uncertainty regarding the sensitivity of reverse transcription polymerase chain reaction in detection of SARS-CoV-2 from nasopharyngeal specimens. We present a case where two nasopharyngeal specimens were negative, followed by a positive sputum sample. Serial testing for COVID-19 is indicated in patients with high pretest probability of disease.

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