Changes in heme levels during acute vaso-occlusive crisis in sickle cell anemia | Zendy

Evilázio Cunha Cardoso | Zendy; Pedro V. da SilvaNeto | Zendy; Bidossessi Wilfried Hounkpe | Zendy; Francine Chénou | Zendy; Cintia Cristina Mateus Xerez Albuquerque | Zendy; Nadja Pinto Garcia | Zendy; Alexander Leonardo Silva-Junior | Zendy; Adriana Malheiro | Zendy; Purim Cesar | Zendy; Franciele de Lima | Zendy; Erich Vinícius De Paula | Zendy; Nelson Abrahim Fraiji | Zendy

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Changes in heme levels during acute vaso-occlusive crisis in sickle cell anemia

Author(s) -

Evilázio Cunha Cardoso,

Pedro V. da SilvaNeto,

Bidossessi Wilfried Hounkpe,

Francine Chénou,

Cintia Cristina Mateus Xerez Albuquerque,

Nadja Pinto Garcia,

Alexander Leonardo Silva-Junior,

Adriana Malheiro,

Purim Cesar,

Franciele de Lima,

Erich Vinícius De Paula,

Nelson Abrahim Fraiji

Publication year - 2021

Publication title -

hematology/oncology and stem cell therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.666

H-Index - 22

eISSN - 1658-3876

pISSN - 2589-0646

DOI - 10.1016/j.hemonc.2021.08.002

Subject(s) - sickle cell anemia , heme , vaso occlusive crisis , occlusive , medicine , anemia , cell , cardiology , chemistry , biochemistry , disease , enzyme

Sickle cell anemia (SCA) is associated with increased levels of extracellular heme, which is a key mediator of inflammation in this condition. Despite abundant evidence supporting this concept in cell and animal models, few studies addressed the association between heme levels and the development and severity of acute vasoocclusive crises (VOC) in humans.

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