Clinicopathological significance of common genetic alterations in patients with acute promyelocytic leukemia | Zendy

Sukanta Nath | Zendy; Jina Bhattacharyya | Zendy; Prem Chandra | Zendy; Renu Saxena | Zendy; Sudha Sazawal | Zendy; Kandarpa Kumar Saikia | Zendy

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Clinicopathological significance of common genetic alterations in patients with acute promyelocytic leukemia

Author(s) -

Sukanta Nath,

Jina Bhattacharyya,

Prem Chandra,

Renu Saxena,

Sudha Sazawal,

Kandarpa Kumar Saikia

Publication year - 2020

Publication title -

hematology/oncology and stem cell therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.666

H-Index - 22

eISSN - 1658-3876

pISSN - 2589-0646

DOI - 10.1016/j.hemonc.2020.07.004

Subject(s) - acute promyelocytic leukemia , npm1 , myeloid leukemia , medicine , leukemia , white blood cell , oncology , immunology , biology , gene , karyotype , retinoic acid , genetics , chromosome

Acute myeloid leukemia (AML) is one of the common forms of hematological malignancy and acute promyelocytic leukemia (APL) is a unique subtype of AML conferring favorable prognosis. We aimed to determine the prevalence and prognostic impact of Fms-like tyrosine kinase 3 (FLT3), nucleophosmin 1 (NPM1) mutation, epidermal growth factor receptor (EGFR), and flow marker's expression in patients with APL.

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