Diffuse large B-Cell lymphoma associated with paraneoplastic Guillain–Barré syndrome: A diagnostic and therapeutic challenge | Zendy

Brototo Deb | Zendy; Manu Pandey | Zendy; Pallawi Torka | Zendy; Suchitra Sundaram | Zendy

Open Access

Diffuse large B-Cell lymphoma associated with paraneoplastic Guillain–Barré syndrome: A diagnostic and therapeutic challenge

Author(s) -

Brototo Deb,

Manu Pandey,

Pallawi Torka,

Suchitra Sundaram

Publication year - 2020

Publication title -

hematology/oncology and stem cell therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.666

H-Index - 22

eISSN - 1658-3876

pISSN - 2589-0646

DOI - 10.1016/j.hemonc.2020.05.008

Subject(s) - chemoimmunotherapy , medicine , guillain barre syndrome , lymphoma , immunotherapy , disease , rituximab , pathology , immunology , cancer

Paraneoplastic neurological syndromes are a rare manifestation of non-Hodgkin lymphoma and can make treatment of these patients more challenging. We report the case of a 67-year-old man with high grade diffuse large B-cell lymphoma who presented with severe paraneoplastic Guillain-Barré syndrome. He was treated with intravenous immunoglobulin therapy and definitive chemoimmunotherapy, and achieved a full neurological recovery. In this report, we discuss various mechanisms of neurological dysfunction seen in lymphomas. Prompt oncologic treatment and immunotherapy for Guillain-Barré syndrome if instituted concurrently and early in the course of the disease can be associated with the best outcomes.

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