Genetic analysis of TMPRSS6 gene in Saudi female patients with iron deficiency anemia | Zendy

Lamiaa H. AlJamea | Zendy; Alexander Woodman | Zendy; Nihal M. Heiba | Zendy; Shereen A. Elshazly | Zendy; Noureddine Ben Khalaf | Zendy; Dahmani M. Fathallah | Zendy; Moudi E. Al-Nashmi | Zendy; Jenifer V. Quiambao | Zendy; Abdel Halim Salem | Zendy

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Genetic analysis of TMPRSS6 gene in Saudi female patients with iron deficiency anemia

Author(s) -

Lamiaa H. AlJamea,

Alexander Woodman,

Nihal M. Heiba,

Shereen A. Elshazly,

Noureddine Ben Khalaf,

Dahmani M. Fathallah,

Moudi E. Al-Nashmi,

Jenifer V. Quiambao,

Abdel Halim Salem

Publication year - 2020

Publication title -

hematology/oncology and stem cell therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.666

H-Index - 22

eISSN - 1658-3876

pISSN - 2589-0646

DOI - 10.1016/j.hemonc.2020.04.007

Subject(s) - tmprss6 , hepcidin , iron deficiency anemia , exon , biology , genetics , gene , untranslated region , allele , anemia , medicine , biochemistry , rna , serine protease , protease , enzyme

Mutations in transmembrane protease serine 6 (TMPRSS6) gene induce high hepcidin level, which causes iron-refractory iron deficiency anemia (IRIDA) by preventing duodenal iron absorption. This study aims to identify the common genetic variations of the TMPRSS6 gene that affect iron levels among Saudi female patients with iron deficiency anemia (IDA).

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