Proceeding of the European Group for Blood and Marrow Transplantation (EBMT) congress on sickle cell disease, 16–17 may 2019, Regensburg, Germany | Zendy

Lisa V. E. Oostenbrink | Zendy; Cornelia M. Jolvan der Zijde | Zendy; Anja M. Jansen-Hoogendijk | Zendy; Emma S. Pool | Zendy; Astrid G. S. van Halteren | Zendy; Dirk Jan A. R. Moes | Zendy; Robbert G. M. Bredius | Zendy; Alex B. Mohseny | Zendy; Frans J. Smiers | Zendy; Maarten J. D. van Tol | Zendy; Marco W. Schilham | Zendy; Arjan C. Lankester | Zendy

Open Access

Proceeding of the European Group for Blood and Marrow Transplantation (EBMT) congress on sickle cell disease, 16–17 may 2019, Regensburg, Germany

Author(s) -

Lisa V. E. Oostenbrink,

Cornelia M. Jolvan der Zijde,

Anja M. Jansen-Hoogendijk,

Emma S. Pool,

Astrid G. S. van Halteren,

Dirk Jan A. R. Moes,

Robbert G. M. Bredius,

Alex B. Mohseny,

Frans J. Smiers,

Maarten J. D. van Tol,

Marco W. Schilham,

Arjan C. Lankester

Publication year - 2020

Publication title -

hematology/oncology and stem cell therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.666

H-Index - 22

eISSN - 1658-3876

pISSN - 2589-0646

DOI - 10.1016/j.hemonc.2019.12.003

Subject(s) - dosing , hematopoietic stem cell transplantation , medicine , conditioning regimen , disease , transplantation , pharmacodynamics , immunology , regimen , pharmacokinetics , globulin , oncology

Antithymocyte globulin (ATG) is a widely accepted part of the conditioning regimen applied in the setting of hematopoietic stem cell transplantation (HSCT) to prevent graft rejection and graft-versus-host disease. Although weight-based dosing of ATG has been introduced to optimize ATG dosing, substantial variance in clearance of active ATG, the actual lymphocyte binding component, remains a challenge. Therefore, further research regarding ATG pharmacokinetics and pharmacodynamics in different HSCT settings and in patients with different types of underlying diseases is required.

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