What is the place of hematopoietic stem cell transplantation in the management of cerebral vasculopathy in children with sickle cell anemia? | Zendy

Françoise Bernaudin | Zendy

Open Access

What is the place of hematopoietic stem cell transplantation in the management of cerebral vasculopathy in children with sickle cell anemia?

Author(s) -

Françoise Bernaudin

Publication year - 2020

Publication title -

hematology/oncology and stem cell therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.666

H-Index - 22

eISSN - 1658-3876

pISSN - 2589-0646

DOI - 10.1016/j.hemonc.2019.12.002

Subject(s) - medicine , sickle cell anemia , transcranial doppler , hematopoietic stem cell transplantation , sibling , anemia , transplantation , stem cell , pediatrics , complication , disease , psychology , developmental psychology , biology , genetics

Cerebral vasculopathy is the most severe complication affecting children with sickle cell anemia. Significant progress has been made in the management of sickle cell anemia cerebral vasculopathy, including early transcranial Doppler screening, chronic transfusion, andhydroxyurea. Nevertheless, for patients with a potential matched-sibling donor (MSD), stem cell transplantation (SCT) is now the treatment offering the best cerebral vasculopathy outcome. In the absence of MSD,alternative SCT should be recommended only in those with worsening cerebral vasculopathy despite standard treatments, and should be limited to related haplo-identical SCT undertaken in controlled studies.

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