Epigenetic changes in FOXO3 and CHEK2 genes and their correlation with clinicopathological findings in myelodysplastic syndromes | Zendy

Mohammad Jafar Sharifi | Zendy; Farhad Zaker | Zendy; Nahid Nasiri | Zendy; Marjan Yaghmaie | Zendy

Open Access

Epigenetic changes in FOXO3 and CHEK2 genes and their correlation with clinicopathological findings in myelodysplastic syndromes

Author(s) -

Mohammad Jafar Sharifi,

Farhad Zaker,

Nahid Nasiri,

Marjan Yaghmaie

Publication year - 2020

Publication title -

hematology/oncology and stem cell therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.666

H-Index - 22

eISSN - 1658-3876

pISSN - 2589-0646

DOI - 10.1016/j.hemonc.2019.11.004

Subject(s) - epigenetics , chek2 , foxo3 , myelodysplastic syndromes , gene , correlation , genetics , biology , cancer research , medicine , mutation , mathematics , transcription factor , bone marrow , germline mutation , geometry

Myelodysplastic syndromes (MDSs) are a heterogeneous disease in terms of clinical course and response to therapy. Epigenetic changes are the primary mechanism of MDS pathogenesis. FOXO3 and CHEK2 genes play significant roles in normal cellular mechanisms and are also known as tumor suppressor genes. We aimed to clarify the correlation of epigenetic changes in these genes with clinicopathologic findings in MDS.

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