Influence of major histocompatibility complex class I chain-related gene A polymorphisms on cytomegalovirus disease after allogeneic hematopoietic cell transplantation | Zendy

Sagar S. Patel | Zendy; Lisa Rybicki | Zendy; Melissa Yurch | Zendy; Dawn Thomas | Zendy; Hien Liu | Zendy; Robert M. Dean | Zendy; Deepa Jagadeesh | Zendy; Brian T. Hill | Zendy; Brad Pohlman | Zendy; Brian J. Bolwell | Zendy; Rabi Hanna | Zendy; Betty K. Hamilton | Zendy; Matt Kalaycio | Zendy; Aaron T. Gerds | Zendy; Eric Cober | Zendy; Sherif B. Mossad | Zendy; Aiwen Zhang | Zendy; Navneet S. Majhail | Zendy; Medhat Askar | Zendy; Ronald Sobecks | Zendy

Open Access

Influence of major histocompatibility complex class I chain-related gene A polymorphisms on cytomegalovirus disease after allogeneic hematopoietic cell transplantation

Author(s) -

Sagar S. Patel,

Lisa Rybicki,

Melissa Yurch,

Dawn Thomas,

Hien Liu,

Robert M. Dean,

Deepa Jagadeesh,

Brian T. Hill,

Brad Pohlman,

Brian J. Bolwell,

Rabi Hanna,

Betty K. Hamilton,

Matt Kalaycio,

Aaron T. Gerds,

Eric Cober,

Sherif B. Mossad,

Aiwen Zhang,

Navneet S. Majhail,

Medhat Askar,

Ronald Sobecks

Publication year - 2019

Publication title -

hematology/oncology and stem cell therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.666

H-Index - 22

eISSN - 1658-3876

pISSN - 2589-0646

DOI - 10.1016/j.hemonc.2019.10.001

Subject(s) - immunology , histocompatibility , transplantation , hematopoietic stem cell transplantation , major histocompatibility complex , disease , cytomegalovirus , gene , minor histocompatibility antigen , hematopoietic cell , biology , human leukocyte antigen , medicine , haematopoiesis , genetics , virology , stem cell , viral disease , herpesviridae , virus , antigen , pathology

Cytomegalovirus (CMV) infection and disease are common infectious complications after allogeneic hematopoietic cell transplantation (alloHCT). Major histocompatibility complex (MHC) class I chain-related gene A (MICA) is a ligand of the natural killer (NKG2D) receptor on immune effector cells that helps mediate NK cell alloreactivity. We hypothesized that MICA polymorphisms may influence CMV infection and disease incidence after alloHCT.

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