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Autologous stem cell transplantation may be curative for patients with follicular lymphoma with early therapy failure without the need for immunotherapy
Author(s) -
Ana Jiménez Ubieto,
Carlos Grande,
Dolores Caballero,
Lucrecia Yáñez,
Silvaovelli,
Miguel Teodoro HernándezGarcia,
María Manzanares,
Reyes Arranz,
José Luis Ferreiro,
Sabela Bobillo,
Santiago Mercadal,
Andrea Galeo,
Javier López Jiménez,
José M. Moraleda,
Carlos Vallejo,
Carmen Albó,
Elena Pérez,
Carmen Marrero,
Laura Magnano,
Luis Palomera,
Isidro Jarque,
Antonia Rodríguez,
Leyre Lorza,
Alejandro Martı́n,
Erika Coria,
Armando LópezGuillermo,
Antonio Salar,
Juan José Lahuerta
Publication year - 2019
Publication title -
hematology/oncology and stem cell therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 22
eISSN - 1658-3876
pISSN - 2589-0646
DOI - 10.1016/j.hemonc.2019.06.001
Subject(s) - medicine , rituximab , autologous stem cell transplantation , cohort , oncology , follicular lymphoma , chemotherapy , lymphoma , overall survival , progression free survival , surgery
Patients with follicular lymphoma (FL) with early therapy failure (ETF) within 2 years of frontline therapy have poor overall survival (OS). We recently reported the results of autologous stem cell transplantation (ASCT) in patients from the Grupo Español de Linfomas y Trasplantes de Médula Ósea (GELTAMO) registry treated with rituximab prior to ASCT and with ETF after first-line immunochemotherapy, leading to 81% 5-year OS since ASCT. We explored whether ASCT is also an effective option in the pre-rituximab era-that is, in patients treated in induction and rescued only with chemotherapy.

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