Epidemiological, clinical, and severity characterization of sickle cell disease in a population from the Brazilian Amazon | Zendy

Purim Cesar | Zendy; Anamika Dhyani | Zendy; Luiz Augusto Schwade | Zendy; Pollyana Acordi | Zendy; Cinthia Xerez de Albuquerque | Zendy; Rejane Nina | Zendy; Erich Vinícius De Paula | Zendy; Nelson Abrahim Fraiji | Zendy

Open Access

Epidemiological, clinical, and severity characterization of sickle cell disease in a population from the Brazilian Amazon

Author(s) -

Purim Cesar,

Anamika Dhyani,

Luiz Augusto Schwade,

Pollyana Acordi,

Cinthia Xerez de Albuquerque,

Rejane Nina,

Erich Vinícius De Paula,

Nelson Abrahim Fraiji

Publication year - 2019

Publication title -

hematology/oncology and stem cell therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.666

H-Index - 22

eISSN - 1658-3876

pISSN - 2589-0646

DOI - 10.1016/j.hemonc.2019.04.002

Subject(s) - amazon rainforest , epidemiology , disease , population , medicine , geography , environmental health , biology , pathology , ecology

Sickle cell disease (SCD) is a chronic inflammatory condition caused by a point mutation in the HBB gene. Here we characterized the clinical presentation of SCD in a population from Amazonas State in northern Brazil, in order to evaluate whether the higher Amerindian ancestry observed in this relatively isolated geographic region would influence the clinical presentation of SCD.

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