Phenotypic characterization of malignant progenitor cells in patients with idiopathic myelofibrosis | Zendy

Yonghua Bao | Zendy; WenYang Hu | Zendy; Yongchen Guo | Zendy; Wancai Yang | Zendy

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Phenotypic characterization of malignant progenitor cells in patients with idiopathic myelofibrosis

Author(s) -

Yonghua Bao,

WenYang Hu,

Yongchen Guo,

Wancai Yang

Publication year - 2019

Publication title -

hematology/oncology and stem cell therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.666

H-Index - 22

eISSN - 1658-3876

pISSN - 2589-0646

DOI - 10.1016/j.hemonc.2019.01.001

Subject(s) - cd34 , haematopoiesis , progenitor cell , biology , stem cell , bone marrow , interleukin 3 , population , cancer research , microbiology and biotechnology , immunology , medicine , interleukin 21 , t cell , immune system , environmental health

Idiopathic myelofibrosis (IM) is a clonal hematological malignancy originating from pluripotent hematopoietic stem cells (HSC). HSC are very rare potent cells that reside in the bone marrow (BM) and at a lower level in peripheral blood (PB). Previous studies showed that IM PB CD34 + cells contain not only BM repopulating cells belonging to the malignant clone but also residual normal HSC.

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