Open AccessLow-dose radiotherapy for extranodal marginal zone B lymphoma of the lip: Case report and literature review
Author(s) -
Lavinia Bianco,
Salvatore Dario Solla,
Guido Parvis,
Eva Gino,
Enrico Bollito,
Andrea Riccardo Filippi,
Francesca Massa,
Maria Grazia Ruo Redda
Publication year - 2018
Publication title -
hematology/oncology and stem cell therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 22
eISSN - 1658-3876
pISSN - 2589-0646
DOI - 10.1016/j.hemonc.2018.12.002
Subject(s) - medicine , radiation therapy , stage (stratigraphy) , chemotherapy , lymphoma , progressive disease , disease , marginal zone b cell lymphoma , radiology , complete response , toxicity , oncology , marginal zone , nuclear medicine , surgery , b cell , immunology , paleontology , antibody , biology
Non-Hodgkin lymphoma (NHL) of the lip is extremely rare. It is usually indolent and in early stages a local approach is often indicated. We present a case report of a patient with extranodal NHL of the lip treated with chemotherapy and low-dose radiation treatment (RT). The patient was affected by B-cell NHL of the marginal zone, Stage IAE. After a few months of observation with progressive disease, the patient was submitted to two cycles of chemotherapy with no response. Therefore, he was treated with very low-dose RT consisting of two fractions of 2 Gy. Complete response was observed and after 1-year follow-up, persistent complete response was recorded. In cases of localized disease, especially in patients with comorbidities of poor performance status (PS), low-dose RT can be an appropriate approach with excellent outcomes in terms of effectiveness and low risk of toxicity.
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