Impact of CD39 expression on CD4+ T lymphocytes and 6q deletion on outcome of patients with chronic lymphocytic leukemia | Zendy

Eman M. Zaki | Zendy; Asmaa M. Zahran | Zendy; Alshimaa Abdelazeem Metwaly | Zendy; Rania Hafez | Zendy; Safinaz Hussein | Zendy; Abdallah Elaiw Mohammed | Zendy

Open Access

Impact of CD39 expression on CD4+ T lymphocytes and 6q deletion on outcome of patients with chronic lymphocytic leukemia

Author(s) -

Eman M. Zaki,

Asmaa M. Zahran,

Alshimaa Abdelazeem Metwaly,

Rania Hafez,

Safinaz Hussein,

Abdallah Elaiw Mohammed

Publication year - 2018

Publication title -

hematology/oncology and stem cell therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.666

H-Index - 22

eISSN - 1658-3876

pISSN - 2589-0646

DOI - 10.1016/j.hemonc.2018.09.002

Subject(s) - chronic lymphocytic leukemia , leukemia , immunology , expression (computer science) , medicine , outcome (game theory) , biology , cancer research , oncology , computer science , mathematics , mathematical economics , programming language

Chronic lymphocytic leukemia is one of the commonest leukemias affecting adults. CD39 inhibits T-cell and Natural killer (NK) cell responses by hydrolyzing adenosine triphosphate and adenosine diphosphate, suppressing the immune system. We investigated expression of CD39 on CD4+ T Lymphocytes in chronic lymphocytic leukemia (CLL) patients and its relationship with deletion 6q, its association with disease stage and survival.

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