DNMT3A (R882) mutation features and prognostic effect in acute myeloid leukemia in Coexistent with NPM1 and FLT3 mutations | Zendy

Dushyant Kumar | Zendy; Anurag Mehta | Zendy; Manoj Kumar Panigrahi | Zendy; Sukanta Nath | Zendy; Kandarpa Kumar Saikia | Zendy

Open Access

DNMT3A (R882) mutation features and prognostic effect in acute myeloid leukemia in Coexistent with NPM1 and FLT3 mutations

Author(s) -

Dushyant Kumar,

Anurag Mehta,

Manoj Kumar Panigrahi,

Sukanta Nath,

Kandarpa Kumar Saikia

Publication year - 2017

Publication title -

hematology/oncology and stem cell therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.666

H-Index - 22

eISSN - 1658-3876

pISSN - 2589-0646

DOI - 10.1016/j.hemonc.2017.09.004

Subject(s) - npm1 , myeloid leukemia , mutation , cancer research , medicine , leukemia , myeloid , oncology , genetics , biology , gene , karyotype , chromosome

In the absence of high-risk cytogenetic, DNMT3A (DNA Methyltransferase 3a) mutation status has an impact on outcome in the presence of FLT3 (FMS-like Tyrosine Kinase3) and/or NPM1 (Nucleophosmin). In this study, we focus on the features and effect of DNMT3A (R882) mutation in acute myeloid leukemia (AML) in the presence or absence of NPM1 and FLT3 mutations.

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