Open AccessHydroxyurea for nontransfusion-dependent β-thalassemia: A systematic review and meta-analysis
Author(s) -
Ali H. Algiraigri,
Nicola Wright,
Elizabeth Oddone Paolucci,
Aliya Kassam
Publication year - 2017
Publication title -
hematology/oncology and stem cell therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 22
eISSN - 1658-3876
pISSN - 2589-0646
DOI - 10.1016/j.hemonc.2017.02.002
Subject(s) - meta analysis , thalassemia , medicine , computer science
Nontransfusion-dependent β-thalassemia (NTDβT) syndromes consist of β-thalassemia intermedia and moderate hemoglobin E/β thalassemias. They are characterized by varying degrees of chronic anemia and a wide spectrum of complications due to ineffective erythropoiesis and iron overload from chronic transfusions. Hydroxyurea (HU), an oral chemotherapeutic drug, is anticipated to decrease disease severity.
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