CXCR4 (CD184) expression on stem cell harvest and CD34 + cells post-transplant | Zendy

Inas A. Asfour | Zendy; Hanaa Afify | Zendy; Shaza Abdel-Wahab Ahmed ELKourashy | Zendy; Maryse Ayoub | Zendy; Gihan Kamal | Zendy; Mary Gamal | Zendy; Ghada Elgohary | Zendy

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CXCR4 (CD184) expression on stem cell harvest and CD34 + cells post-transplant

Author(s) -

Inas A. Asfour,

Hanaa Afify,

Shaza Abdel-Wahab Ahmed ELKourashy,

Maryse Ayoub,

Gihan Kamal,

Mary Gamal,

Ghada Elgohary

Publication year - 2017

Publication title -

hematology/oncology and stem cell therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.666

H-Index - 22

eISSN - 1658-3876

pISSN - 2589-0646

DOI - 10.1016/j.hemonc.2017.01.002

Subject(s) - cxcr4 , medicine , cd34 , homing (biology) , stem cell , bone marrow , multiple myeloma , haematopoiesis , myeloid leukemia , lymphoma , transplantation , immunology , aplastic anemia , hematopoietic stem cell transplantation , leukemia , stromal cell , cancer research , biology , chemokine , immune system , ecology , genetics

CXCR4 is a receptor for stromal-derived factor-1 (SDF-1), a molecule that has a chemotactic activity for lymphocytes and is important in homing of hematopoietic stem cells to their adult marrow. We evaluated the CXCR4 (CD184) expression in the harvest cells and in the post-transplant bone marrow (BM) and its relation to engraftment, as determined by the consensus criteria and chimerism.

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