Open AccessEpigallocatechin gallate (EGCG) suppresses lipopolysaccharide‐induced inflammatory bone resorption, and protects against alveolar bone loss in mice
Author(s) -
Tominari Tsukasa,
Matsumoto Chiho,
Watanabe Kenta,
Hirata Michiko,
Grundler Florian M.W.,
Miyaura Chisato,
Inada Masaki
Publication year - 2015
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1016/j.fob.2015.06.003
Subject(s) - bone resorption , resorption , osteoclast , dental alveolus , chemistry , lipopolysaccharide , prostaglandin e2 , rankl , in vivo , epigallocatechin gallate , catechin , endocrinology , in vitro , medicine , microbiology and biotechnology , biochemistry , antioxidant , polyphenol , biology , dentistry , receptor , activator (genetics)
Epigallocatechin gallate (EGCG), a major polyphenol in green tea, possesses antioxidant properties and regulates various cell functions. Here, we examined the function of EGCG in inflammatory bone resorption. In calvarial organ cultures, lipopolysaccharide (LPS)‐induced bone resorption was clearly suppressed by EGCG. In osteoblasts, EGCG suppressed the LPS‐induced expression of COX‐2 and mPGES‐1 mRNAs, as well as prostaglandin E2 production, and also suppressed RANKL expression, which is essential for osteoclast differentiation. LPS‐induced bone resorption of mandibular alveolar bones was attenuated by EGCG in vitro , and the loss of mouse alveolar bone mass was inhibited by the catechin in vivo .