Open Access4‐Oxo‐( E )‐2‐hexenal produced by Heteroptera induces permanent locomotive impairment in crickets that correlates with free thiol depletion
Author(s) -
Noge Koji,
Becerra Judith X.
Publication year - 2015
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1016/j.fob.2015.04.004
Subject(s) - thiol , heteroptera , adduct , chemistry , insect , covalent bond , zoology , biochemistry , biology , ecology , organic chemistry
Heteropterans produce 2‐alkenals and 4‐keto‐2‐alkenals that function as defense substances or pheromones. However, in spite of advances in heteropteran chemistry, it is still unclear how these compounds affect insect physiology. We found that exposure to 4‐oxo‐( E )‐2‐hexenal (OHE) induced permanent paralysis and death in crickets, an experimental model. The depletion of free thiols in leg tissues of OHE‐treated crickets and the in vitro adduct formation of OHE with a thiol compound suggest that covalent binding of OHE to biologically active thiols is a potential cause affecting crickets’ locomotion.