Open AccessRole of histamine H 3 receptor in glucagon‐secreting αTC1.6 cells
Author(s) -
Nakamura Tadaho,
Yoshikawa Takeo,
Naganuma Fumito,
Mohsen Attayeb,
Iida Tomomitsu,
Miura Yamato,
Sugawara Akira,
Yanai Kazuhiko
Publication year - 2015
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1016/j.fob.2014.12.001
Subject(s) - histamine , endocrinology , medicine , glucagon , receptor , secretion , agonist , homeostasis , intracellular , chemistry , biology , microbiology and biotechnology , insulin
Pancreatic α‐cells secrete glucagon to maintain energy homeostasis. Although histamine has an important role in energy homeostasis, the expression and function of histamine receptors in pancreatic α‐cells remains unknown. We found that the histamine H 3 receptor (H 3 R) was expressed in mouse pancreatic α‐cells and αTC1.6 cells, a mouse pancreatic α‐cell line. H 3 R inhibited glucagon secretion from αTC1.6 cells by inhibiting an increase in intracellular Ca 2+ concentration. We also found that immepip, a selective H 3 R agonist, decreased serum glucagon concentration in rats. These results suggest that H 3 R modulates glucagon secretion from pancreatic α‐cells.