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Pancreatic α‐cells secrete glucagon to maintain energy homeostasis. Although histamine has an important role in energy homeostasis, the expression and function of histamine receptors in pancreatic α‐cells remains unknown. We found that the histamine H 3  receptor (H 3 R) was expressed in mouse pancreatic α‐cells and αTC1.6 cells, a mouse pancreatic α‐cell line. H 3 R inhibited glucagon secretion from αTC1.6 cells by inhibiting an increase in intracellular Ca 2+  concentration. We also found that immepip, a selective H 3 R agonist, decreased serum glucagon concentration in rats. These results suggest that H 3 R modulates glucagon secretion from pancreatic α‐cells.

Role of histamine H 3 receptor in glucagon‐secreting αTC1.6 cells