Open AccessElucidating the host–pathogen interaction between human colorectal cells and invading Enterovirus 71 using transcriptomics profiling
Author(s) -
Lui Yan Long Edmund,
Tan Tuan Lin,
Timms Peter,
Hafner Louise Marie,
Tan Kian Hwa,
Tan Eng Lee
Publication year - 2014
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1016/j.fob.2014.04.005
Subject(s) - transcriptome , enterovirus 71 , biology , immune system , pathogen , gene expression profiling , microarray , disease , pathogenesis , microarray analysis techniques , genome , virology , enterovirus , gene , computational biology , immunology , gene expression , medicine , genetics , virus , pathology
Enterovirus 71 (EV71) is one of the main etiological agents for Hand, Foot and Mouth Disease (HFMD) and has been shown to be associated with severe clinical manifestation. Currently, there is no antiviral therapeutic for the treatment of HFMD patients owing to a lack of understanding of EV71 pathogenesis. This study seeks to elucidate the transcriptomic changes that result from EV71 infection. Human whole genome microarray was employed to monitor changes in genomic profiles between infected and uninfected cells. The results reveal altered expression of human genes involved in critical pathways including the immune response and the stress response. Together, data from this study provide valuable insights into the host–pathogen interaction between human colorectal cells and EV71.