Open AccessOrigin and evolution of the Peptidyl Transferase Center from proto‐tRNAs
Author(s) -
Farias Sávio T.,
Rêgo Thais G.,
José Marco V.
Publication year - 2014
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1016/j.fob.2014.01.010
Subject(s) - peptidyl transferase , ribosome , transfer rna , 23s ribosomal rna , ribosomal rna , biology , rna , genetics , p site , 50s , transferase , biochemistry , enzyme , gene
We tested the hypothesis of Tamura (2011) [3] that molecules of tRNA gave origin to ribosomes, particularly to the Peptidyl Transferase Center (PTC) of the 23S ribosomal RNA. We reconstructed the ancestral sequences from all types of tRNA and compared them in their sequences with the current PTC of 23S ribosomal RNA from different organisms. We built an ancestral sequence of proto‐tRNAs that showed a remarkable overall identity of 50.53% with the catalytic site of PTC. We conclude that the Peptidyl Transferase Center was indeed originated by the fusion of ancestral sequences of proto‐tRNA.