Open AccessIdentification of myo‐inositol hexakisphosphate (IP6) as a β‐secretase 1 (BACE1) inhibitory molecule in rice grain extract and digest
Author(s) -
Abe Takako K.,
Taniguchi Masayuki
Publication year - 2014
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1016/j.fob.2014.01.008
Subject(s) - inhibitory postsynaptic potential , inositol , amyloid precursor protein , cytotoxicity , peptide , ic50 , chemistry , biochemistry , amyloid β , cleavage (geology) , neuroblastoma , in vitro , biology , disease , alzheimer's disease , receptor , cell culture , medicine , endocrinology , genetics , paleontology , fracture (geology)
Alzheimer's disease (AD) is widely considered to be caused by amyloid‐β peptide (Aβ) accumulation in the brain. Aβ is excised from amyloid‐β precursor protein through sequential cleavage by β‐secretase 1 (BACE1) and γ‐secretase. Thus, BACE1 inhibition could prevent Aβ accumulation. Here, we identified myo‐inositol hexakisphosphate (IP6) as a BACE1 inhibitory molecule in rice grain extract and digest. The rice digest and IP6 significantly inhibited Aβ production in neuroblastoma cells without cytotoxicity. These results suggested that rice components, including IP6, may be promising starting materials for the development of potent and safe drugs and/or food to prevent AD.