Open AccessThe ALS/FTLD‐related RNA‐binding proteins TDP‐43 and FUS have common downstream RNA targets in cortical neurons
Author(s) -
Honda Daiyu,
Ishigaki Shinsuke,
Iguchi Yohei,
Fujioka Yusuke,
Udagawa Tsuyoshi,
Masuda Akio,
Ohno Kinji,
Katsuno Masahisa,
Sobue Gen
Publication year - 2014
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1016/j.fob.2013.11.001
Subject(s) - frontotemporal lobar degeneration , amyotrophic lateral sclerosis , rna splicing , rna binding protein , rna , biology , gene expression , alternative splicing , microbiology and biotechnology , gene , neuroscience , messenger rna , frontotemporal dementia , genetics , disease , pathology , medicine , dementia
TDP‐43 and FUS are linked to amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), and loss of function of either protein contributes to these neurodegenerative conditions. To elucidate the TDP‐43‐ and FUS‐regulated pathophysiological RNA metabolism cascades, we assessed the differential gene expression and alternative splicing profiles related to regulation by either TDP‐43 or FUS in primary cortical neurons. These profiles overlapped by >25% with respect to gene expression and >9% with respect to alternative splicing. The shared downstream RNA targets of TDP‐43 and FUS may form a common pathway in the neurodegenerative processes of ALS/FTLD.