Open AccessAtrophy of myoepithelial cells in parotid glands of diabetic mice; detection using skeletal muscle actin, a novel marker
Author(s) -
Nashida Tomoko,
Yoshie Sumio,
Haga-Tsujimura Maiko,
Imai Akane,
Shimomura Hiromi
Publication year - 2013
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1016/j.fob.2013.01.009
Subject(s) - myoepithelial cell , actin , skeletal muscle , atrophy , muscle atrophy , nod , biology , pathology , endocrinology , microbiology and biotechnology , medicine , immunohistochemistry , diabetes mellitus
In mouse parotid glands, we found expression of skeletal muscle actin (actin‐α1) protein and mRNA. We isolated myoepithelial cells from the mouse parotid glands and investigated their actin‐α1 expression because smooth muscle actin (actin‐α2) has been used as a marker for myoepithelial cells. We used actin‐α1 expression to identify pathological changes in diabetic non‐obese diabetic (NOD; NOD/ShiJcl) mice—a mouse model for Sjögren's syndrome—and found myoepithelial cells to be decreased or atrophied in the diabetic state.