Open AccessResolvin E1 maintains macrophage function under cigarette smoke‐induced oxidative stress
Author(s) -
Takamiya Rina,
Fukunaga Koichi,
Arita Makoto,
Miyata Jun,
Seki Hiroyuki,
Minematsu Naoto,
Suematsu Makoto,
Asano Koichiro
Publication year - 2012
Publication title -
febs open bio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.718
H-Index - 31
ISSN - 2211-5463
DOI - 10.1016/j.fob.2012.10.001
Subject(s) - macrophage , oxidative stress , cigarette smoke , superoxide , microbiology and biotechnology , function (biology) , chemistry , alveolar macrophage , biochemistry , biology , toxicology , in vitro , enzyme
Cigarette smoke (CS) induces oxidative stress, which disables macrophage function. In this study, we examined whether Resolvin E1 (RvE1), a pro‐resolving mediator known to enhance macrophage functions, attenuates the damage of macrophages by CS extract (CSE) induced oxidative stress. RvE1 blocked p47phox translocation to plasma membrane induced by CSE in a macrophage cell line, RAW264.7 cells, resulting in suppression of superoxide production. Furthermore, pretreatment of RAW264.7 cells with RvE1 restored the phagocytic activity and reduced cell death induced by treatment of CSE. These results suggest that RvE1 plays important roles in preserving macrophage function under CS‐induced oxidative stress.