Metabolomic profiling reveals that  Drosophila melanogaster  larvae with the  y  mutation have altered lysine metabolism | Zendy

Bratty Mohammed Al | Zendy; Chintapalli Venkateswara R. | Zendy; Dow Julian A.T. | Zendy; Zhang Tong | Zendy; Watson David G. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Metabolomic profiling reveals that Drosophila melanogaster larvae with the y mutation have altered lysine metabolism

Author(s) -

Bratty Mohammed Al,

Chintapalli Venkateswara R.,

Dow Julian A.T.,

Zhang Tong,

Watson David G.

Publication year - 2012

Publication title -

febs open bio

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.718

H-Index - 31

ISSN - 2211-5463

DOI - 10.1016/j.fob.2012.07.007

Subject(s) - metabolomics , drosophila melanogaster , lysine , metabolism , biology , genetics , mutation , profiling (computer programming) , biochemistry , computational biology , bioinformatics , amino acid , gene , computer science , operating system

Yellow ( y ) encodes a protein which is closely similar to major royal jelly proteins produced by bees. However, the function of y remains largely unknown. Metabolomic profiling was carried out on third instar Oregon R (OR) and yellow ( y ) Drosophila melanogaster larvae. Phenylalanine, tyrosine and DOPA were all elevated in y as might be expected since the mutation blocks melanin biosynthesis. The most consistent effects were related to lysine metabolism, with the lysine metabolite saccharopine being much higher in y . In addition, lysine acetate was elevated, and the levels of methyl lysines were lower, in y than in OR.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research