Open AccessFuro[2,3-d]pyrimidine based derivatives as kinase inhibitors and anticancer agents
Author(s) -
M. Abdel Aziz,
Rabah A. T. Serya,
Deena S. Lasheen,
Khaled A.M. Abouzid
Publication year - 2016
Publication title -
future journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
eISSN - 2314-7253
pISSN - 2314-7245
DOI - 10.1016/j.fjps.2015.12.001
Subject(s) - pyrimidine , enzyme , kinase , chemistry , ring (chemistry) , purine , biochemistry , protein kinase a , stereochemistry , combinatorial chemistry , organic chemistry
Furopyrimidines are fused heterocyclic ring systems. Structurally, they are bioisoteres to purines and exerting pharmacological actions in various aspects. They are known to play an important role in different disease conditions. Furo[2,3-d]pyrimidines derivatives have been explored for their inhibitory activity against different protein kinase enzymes. The present review, to the best of our knowledge, is the first compilation on synthesis, anticancer activity, via inhibition of various protein kinase enzymes, and structure–activity relationships of furo[2,3-d]pyrimidines derivatives reported to date