Premium
Global mapping of the regulatory interactions of histone residues
Author(s) -
Jung Inkyung,
Seo Jungmin,
Lee Heun-Sik,
Stanton Lawrence W.,
Kim Dongsup,
Choi Jung Kyoon
Publication year - 2015
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2015.11.016
Subject(s) - histone , nucleosome , chromatin , histone code , acetylation , histone h2a , histone methyltransferase , histone methylation , biology , crosstalk , microbiology and biotechnology , histone h3 , genetics , biochemistry , dna methylation , gene expression , gene , physics , optics
Histone residues can serve as platforms for specific regulatory function. Here we constructed a map of regulatory associations between histone residues and a wide spectrum of chromatin regulation factors based on gene expression changes by histone point mutations in Saccharomyces cerevisiae . Detailed analyses of this map revealed novel associations. Regarding the modulation of H3K4 and K36 methylation by Set1, Set2, or Jhd2, we proposed a role for H4K91 acetylation in early Pol II elongation, and for H4K16 deacetylation in late elongation and crosstalk with H3K4 demethylation for gene silencing. The association of H3K56 with nucleosome positioning suggested that this lysine residue and its acetylation might contribute to nucleosome mobility for transcription activation. Further insights into chromatin regulation are expected from this approach.