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Down‐regulation of 5S rRNA by miR‐150 and miR‐383 enhances c‐Myc–rpL11 interaction and inhibits proliferation of esophageal squamous carcinoma cells
Author(s) -
Wang Xinyu,
Ren Yanli,
Wang Zhiqiong,
Xiong Xiangyu,
Han Sichong,
Pan Wenting,
Chen Hongwei,
Zhou Liqing,
Zhou Changchun,
Yuan Qipeng,
Yang Ming
Publication year - 2015
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2015.11.012
Subject(s) - esophageal squamous cell carcinoma , cancer research , microrna , chemistry , biology , carcinoma , microbiology and biotechnology , medicine , gene , genetics
5S rRNA plays an important part in ribosome biology and is over‐expression in multiple cancers. In this study, we found that 5S rRNA is a direct target of miR‐150 and miR‐383 in esophageal squamous cell carcinoma (ESCC). Overexpression of miR‐150 and miR‐383 inhibited ESCC cell proliferation in vitro and in vivo. Moreover, 5S rRNA silencing by miR‐150 and miR‐383 might intensify rpL11–c‐Myc interaction, which attenuated role of c‐Myc as an oncogenic transcriptional factor and dysregulation of multiple c‐Myc target genes. Taken together, our results highlight the involvement of miRNAs in ribosomal regulation during tumorigenesis.