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Diversity and development of local inhibitory and excitatory neurons associated with dopaminergic nuclei
Author(s) -
Morello Francesca,
Partanen Juha
Publication year - 2015
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2015.10.001
Subject(s) - dopaminergic , neuroscience , glutamatergic , inhibitory postsynaptic potential , forebrain , gabaergic , midbrain , dopaminergic pathways , excitatory postsynaptic potential , striatum , biology , dopamine , central nervous system , glutamate receptor , receptor , biochemistry
For regulation of voluntary movement and motivation the midbrain dopaminergic system receives input from a variety of brain regions. Often this input is mediated by local non‐dopaminergic neurons within or closely associated with the dopaminergic nuclei. In addition to the dopaminergic neurons, some of these non‐dopaminergic neurons also send functionally important output from the ventral midbrain to forebrain targets. The aim of this review is to introduce subtypes of GABAergic and glutamatergic neurons, which are located in the dopaminergic nuclei or the adjacent brainstem and are important for the regulation of the dopaminergic pathways. In addition, we discuss recent studies beginning to reveal mechanisms for their development, which may hold the key to understanding the diversity of these neurons.