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A Cathepsin‐L is required for invasive behavior during Air Sac Primordium development in Drosophila melanogaster
Author(s) -
Dong Qian,
Brenneman Breanna,
Fields Christopher,
Srivastava Ajay
Publication year - 2015
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2015.08.036
Subject(s) - primordium , drosophila melanogaster , biology , microbiology and biotechnology , gene knockdown , morphogenesis , drosophila (subgenus) , cathepsin l , cathepsin , gene , genetics , biochemistry , enzyme
The Drosophila Air Sac Primordium (ASP) has emerged as an important structure where cellular, genetic and molecular events responsible for invasive behavior and branching morphogenesis can be studied. In this report we present data which demonstrate that a Cathepsin‐L encoded by the gene CP1 in Drosophila is necessary for invasive behavior during ASP development. We find that CP1 is expressed in ASP and knockdown of CP1 results in suppression of migratory and invasive behavior observed during ASP development. We further show that CP1 possibly regulates invasive behavior by promoting degradation of Basement Membrane. Our data provide clues to the possible role of Cathepsin L in human lung development and tumor invasion, especially, given the similarities between human lung and Drosophila ASP development.