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Retracted: MicroRNA‐454 functions as an oncogene by regulating PTEN in uveal melanoma
Author(s) -
Sun Lei,
Wang Qiaoling,
Gao Xiangchun,
Shi Dejing,
Mi Shuyong,
Han Qing
Publication year - 2015
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2015.08.007
Subject(s) - pten , microrna , melanoma , oncogene , cancer research , biology , cancer , medicine , genetics , gene , apoptosis , pi3k/akt/mtor pathway , cell cycle
MicroRNAs (miRNAs) regulate gene expression by targeted repression of transcription and translation, and are involved in carcinogenesis. In this study, we demonstrated that the expression of miR‐454 was up‐regulated in uveal melanoma tissues compared to normal tissues. Ectopic expression of miR‐454 resulted in significant promotion of cell proliferation, colony formation, invasion and induction of cell cycle in uveal melanoma cells. Furthermore, we identified PTEN as a direct target of miR‐454. Our data revealed that ectopic expression of PTEN restored the effects of miR‐454 on cell proliferation and invasion in uveal melanoma cells. These findings support an oncogene role of miR‐454 in development of uveal melanoma.