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Chromatin, DNA structure and alternative splicing
Author(s) -
Nieto Moreno Nicolás,
Giono Luciana E.,
Cambindo Botto Adrián E.,
Muñoz Manuel J.,
Kornblihtt Alberto R.
Publication year - 2015
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2015.08.002
Subject(s) - rna splicing , chromatin , alternative splicing , histone , biology , splicing factor , transcription (linguistics) , rna polymerase ii , microbiology and biotechnology , dna , computational biology , genetics , rna , promoter , gene , exon , gene expression , linguistics , philosophy
Coupling of transcription and alternative splicing via regulation of the transcriptional elongation rate is a well‐studied phenomenon. Template features that act as roadblocks for the progression of RNA polymerase II comprise histone modifications and variants, DNA‐interacting proteins and chromatin compaction. These may affect alternative splicing decisions by inducing pauses or decreasing elongation rate that change the time‐window for splicing regulatory sequences to be recognized. Herein we discuss the evidence supporting the influence of template structural modifications on transcription and splicing, and provide insights about possible roles of non‐B DNA conformations on the regulation of alternative splicing.