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Cell reprogramming and neuronal differentiation applied to neurodegenerative diseases: Focus on Parkinson's disease
Author(s) -
Wenker Shirley D.,
Casalía Mariana,
Candedo Verónica Cavaliere,
Casabona Juan Cruz,
Pitossi Fernando J.
Publication year - 2015
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2015.07.023
Subject(s) - reprogramming , induced pluripotent stem cell , neuroscience , parkinson's disease , disease , regenerative medicine , neuroprotection , neurology , medicine , stem cell , biology , cell , pathology , embryonic stem cell , microbiology and biotechnology , biochemistry , genetics , gene
In this review we discuss the advantages and unresolved issues of cell reprogramming and neuronal differentiation. We reviewed evidence using iPSCs‐derived neurons from neurological patients. Focusing on data obtained from Parkinson's disease (PD) patients, we show that iPSC‐derived neurons possess morphological and functional characteristics of this disease and build a case for the use of this technology to study PD and other neuropathologies while disease is in progress. These data show the enormous impact that this new technology starts to have on different purposes such as the study and design of future therapies of neurological disease, especially PD.