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MicroRNA‐410 promotes cell proliferation by targeting BRD7 in non‐small cell lung cancer
Author(s) -
Li Dengrui,
Yang YongHui,
Zhu GuiYun,
Liu XinYan,
Zhao Min,
Li XiaoXia,
Yang QinOu
Publication year - 2015
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/j.febslet.2015.06.031
Subject(s) - microrna , downregulation and upregulation , cancer research , cell growth , protein kinase b , lung cancer , oncogene , cell , phosphorylation , suppressor , biology , cancer , cell cycle , medicine , microbiology and biotechnology , gene , oncology , genetics
miR‐410 acts as an oncogene or tumor suppressor gene in some malignancies. However, its role in NSCLC is still unknown. In this study, we showed that the expression of miR‐410 was up‐regulated in both human NSCLC tissues and cells. Overexpression of miR‐410 promoted cell proliferation, migration, and invasion of NSCLC. In addition, bromodomain‐containing protein 7 (BRD7) was a direct target of miR‐410. MiR‐410‐mediated downregulation of BRD7 led to increase Akt phosphorylation. Inhibition of Akt phosphorylation can rescue the effect of miR‐410 on NSCLC cell. The expression of BRD7 was downregulated in NSCLC and was inversely expressed with miR‐410 in NSCLC. Our data provided new knowledge regarding the role of miR‐410 in the lung cancer progression.