miR‐362‐5p inhibits proliferation and migration of neuroblastoma cells by targeting phosphatidylinositol 3‐kinase‐C2β | Zendy

Wu Kai | Zendy; Yang Liucheng | Zendy; Chen Jianfeng | Zendy; Zhao Haijun | Zendy; Wang Jianjun | Zendy; Xu Shuai | Zendy; Huang Zonghai | Zendy

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miR‐362‐5p inhibits proliferation and migration of neuroblastoma cells by targeting phosphatidylinositol 3‐kinase‐C2β

Author(s) -

Wu Kai,

Yang Liucheng,

Chen Jianfeng,

Zhao Haijun,

Wang Jianjun,

Xu Shuai,

Huang Zonghai

Publication year - 2015

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/j.febslet.2015.05.056

Subject(s) - neuroblastoma , pi3k/akt/mtor pathway , cancer research , gene knockdown , cell growth , suppressor , kinase , phosphatidylinositol , chemistry , biology , microbiology and biotechnology , signal transduction , cell culture , apoptosis , biochemistry , genetics , gene

miR‐362‐5p is down‐regulated in high‐risk neuroblastoma and can function as a tumor suppressor. However, its role remains poorly understood. We show that miR‐362‐5p is down‐regulated in metastatic neuroblastoma compared with primary neuroblastoma. Overexpression of miR‐362‐5p inhibits cell proliferation, migration and invasion of neuroblastoma cells in vitro and suppresses tumor growth of neuroblastoma in vivo. Phosphatidylinositol 3‐kinase (PI3K)‐C2β is a target of miR‐362‐5p. Knockdown of PI3K‐C2β by siRNA had a similar effect to overexpression of miR‐362‐5p on SH‐SY5Y cells. Overexpression of PI3K‐C2β partially reversed tumor‐suppressive effects of miR‐362‐5p. We suggest that miR‐362‐5p suppresses neuroblastoma cell growth and motility, partially by targeting PI3K‐C2β.

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